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Danielle Hulsman

Netherlands Cancer Institute - Division of Molecular Genetics

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Genetic Screens Reveal New Targetable Vulnerabilities in BAP1-Deficient Mesothelioma

Number of pages: 54 Posted: 01 Jul 2022
Gaurav Kumar Pandey, Nick Landman, Hannah K. Neikes, Danielle Hulsman, Cor Lieftink, Roderick Beijersbergen, Krishna Kalyan Kolluri, Sam Janes, Michiel Vermeulen, Jitendra Badhai and Maarten van Lohuizen
Netherlands Cancer Institute - Division of Molecular Genetics, Netherlands Cancer Institute - Division of Molecular Genetics, Radboud University Nijmegen - Department of Molecular Biology, Netherlands Cancer Institute - Division of Molecular Genetics, Netherlands Cancer Institute - Division of Molecular Carcinogenesis, Netherlands Cancer Institute - Division of Molecular Carcinogenesis, University College London - Lung for Living Research Centre, University College London - Lung for Living Research Centre, Radboud University Nijmegen - Department of Molecular Biology, Netherlands Cancer Institute - Division of Molecular Genetics and Netherlands Cancer Institute - Division of Molecular Genetics
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Abstract:

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Mesothelioma, BAP1, Polycomb, Mevalonate pathway, Epigenetics, Drug combinations, EZH2, Zoledronic acid