University of Salamanca - Group for Biomedical Research in Sepsis (BioSepsis), University of Salamanca - Group for Biomedical Research in Sepsis (BioSepsis), affiliation not provided to SSRN, affiliation not provided to SSRN, University of Valladolid - Rio Hortega University Hospital, Hospital Universitario Infanta Leonor - Department of Internal Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, ICU Hospital Universitario de Jerez, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Alcala - Hospital Universitario Príncipe de Asturias, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Salamanca - University Hospital of Salamanca, affiliation not provided to SSRN, INCLIVA Health Research Institute - Hospital Clínico Universitario, Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Instituto de Investigación Sanitaria Hospital "12 de Octubre" - Hospital Universitario 12 de Octubre, Hospital Universitario de León, affiliation not provided to SSRN, affiliation not provided to SSRN, Hospital Universitario La Paz, affiliation not provided to SSRN, Dalhousie University, University of Barcelona - Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona - Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and Independent

affiliation not provided to SSRN, affiliation not provided to SSRN, Instituto de Investigación Sanitaria Hospital "12 de Octubre" - Hospital Universitario 12 de Octubre, Universidad Autónoma de Madrid, “Juan José Crottoggini” Spanish Hospital - Intensive Care Unit, Universidad Complutense de Madrid, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University Hospital of Jaén and affiliation not provided to SSRN