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Dietmar Schmitz

German Center for Neurodegenerative Diseases (DZNE)

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Preclinial Safety and Efficacy of a Therapeutic Antibody That Targets SARS-CoV-2 at the Sotrovimab Face But is Escaped by Omicron

Number of pages: 49 Posted: 17 Aug 2022
Jakob Kreye, S. Momsen Reincke, Stefan Edelburg, Lara M. Jeworowski, Hans-Christian Kornau, Jakob Trimpert, Peter Hombach, Sophia Halbe, Volker Nölle, Martin Meyer, Stefanie Kattenbach, Elisa Sánchez-Sendin, Marie Luisa Schmidt, Tatjana Schwarz, Ruben Rose, Andi Krumbholz, Sophie Merz, Julia M. Adler, Kathrin Eschke, Azza Abdelgawad, Dietmar Schmitz, Leif E. Sander, Uwe Janssen, Victor M. Corman and Harald Prüß
German Center for Neurodegenerative Diseases (DZNE), German Center for Neurodegenerative Diseases (DZNE), Miltenyi Biotec B.V. & Co. KG, Berlin Institute of Health - Institute of Virology, German Center for Neurodegenerative Diseases (DZNE), Free University of Berlin (FUB) - Institut für Virologie, Miltenyi Biotec B.V. & Co. KG, Miltenyi Biotec B.V. & Co. KG, Miltenyi Biotec B.V. & Co. KG, Miltenyi Biotec B.V. & Co. KG, Miltenyi Biotec B.V. & Co. KG, German Center for Neurodegenerative Diseases (DZNE), Charité - Universitätsmedizin Berlin - Institute of Virology, Charité - Universitätsmedizin Berlin - Institute of Virology, Christian Albrechts-University of Kiel - Institute for Infection Medicine, Christian Albrechts-University of Kiel - Institute for Infection Medicine, IDEXX Laboratories, Free University of Berlin (FUB) - Institut für Virologie, Free University of Berlin (FUB) - Institut für Virologie, Free University of Berlin (FUB) - Institut für Virologie, German Center for Neurodegenerative Diseases (DZNE), Charité - Universitätsmedizin Berlin - Department of Infectious Diseases and Respiratory Medicine, Miltenyi Biotec B.V. & Co. KG, Charité - Universitätsmedizin Berlin - Institute of Virology and German Center for Neurodegenerative Diseases (DZNE)
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Abstract:

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COVID-19, SARS-CoV-2, therapeutic antibody, variant of concern, potency breadth, hamster model, human membrane protein library, human tissue cross-reactivity study, Omicron, N440K