Sapienza University of Rome - Department of Maternal, Infantile, and Urological Sciences, Sapienza University of Rome - Department of Molecular Medicine, Sapienza University of Rome - Department of Maternal, Infantile, and Urological Sciences, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Laboratory of Cellular Immunology and Clinical Pharmacology, Bambino Gesù Children's Hospital - Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital - Diagnostic Immunology Research Unit, University of North Carolina (UNC) at Chapel Hill - National Institute of Health, Istituto Superiore di Sanità - Department of Infectious Diseases, Istituto Superiore di Sanità - Department of Infectious Diseases, Istituto Superiore di Sanità - Department of Infectious Diseases, Sapienza University of Rome - Department of Maternal, Infantile, and Urological Sciences, Sapienza University of Rome - Department of Maternal, Infantile, and Urological Sciences, Sapienza University of Rome - Department of Maternal, Infantile, and Urological Sciences, Istituto Superiore di Sanità - Dipartimento Malattie Infettive, Sapienza University of Rome - Department of Maternal, Infantile, and Urological Sciences, Sapienza University of Rome - Department of Maternal, Infantile, and Urological Sciences, Istituto Superiore di Sanità - Department of Infectious Diseases, Sapienza University of Rome - Department of Molecular Medicine, Bambino Gesù Children's Hospital - Department of Pediatric Hematology and Oncology and Bambino Gesù Children's Hospital - Diagnostic Immunology Research Unit