Xiaoxue Zhu

Jilin University (JLU) - First Hospital

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The Enedioic Acid Analogue 326E Alleviates MASH in Preclinical Studies and its Signatures in Patients via Dual Targeting at ACLY and PPARα

Number of pages: 62 Posted: 16 Oct 2024
Zhifu Xie, Long Cheng, Yue Hu, Gaolei Song, Fan Wang, Mei Zhang, Yangming Zhang, Xinwen Zhang, Chendong Zhou, Xiaoxue Zhu, Xinyun Sun, Honghong Xu, Qian Song, Yulin Yang, Jie Zheng, Shaohui Ji, Jiming Ye, Xiaoying Lai, Wei Li, Yifan Zhang, Xiaoyan Chen, Junqi Niu, Yanhua Ding, Fajun Nan, Jing-Ya Li and Sneak Peek Administrator
Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Jilin University (JLU) - First Hospital, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Nanjing University of Chinese Medicine (NJUCM), Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Jilin University (JLU) - First Hospital, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Kunming Biomed International, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Burgeon Therapeutics Co., Ltd., Burgeon Therapeutics Co., Ltd., Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Jilin University (JLU) - Department of Hepatology, Jilin University (JLU) - First Hospital, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research, Chinese Academy of Sciences (CAS) - State Key Laboratory of Drug Research and Independent
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Abstract:

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Metabolic dysfunction-associated steatohepatitis, 326E, ACLY, lipogenesis, PPARα, fatty acid β-oxidation, phase 1b/2a clinical trial