Sapienza University of Rome - Department of Physiology and Pharmacology, Sapienza University of Rome - Department of Physiology and Pharmacology, Sapienza University of Rome - Department of Physiology and Pharmacology, Sapienza University of Rome - Department of Physiology and Pharmacology, Sapienza University of Rome - Department of Physiology and Pharmacology, University of Naples Parthenope, IRCCS Synlab SDN, Oasi Research Institute - IRCCS, Oasi Research Institute - IRCCS, IRCCS Ospedale Policlinico San Martino, IRCCS Ospedale Policlinico San Martino, Università degli Studi di Genova, Istanbul Medipol University, Izmir University of Economics, IRCCS San Raffaele Pisana, IRCCS San Raffaele Pisana, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Sapienza University of Rome, Istanbul Medipol University, Istanbul Medipol University, Dokuz Eylül University, IRCCS Centro San Giovanni di Dio Fatebenefratelli and IRCCS Synlab SDN