Imperial College London - Imperial Centre for Cardiovascular Disease Prevention, Daiichi Sankyo Europe, Daiichi Sankyo Europe, Daiichi Sankyo Europe, Daiichi Sankyo Europe, Nankai University - Heart Institute, Sapienza University of Rome - Department of Translational and Precision Medicine, Barking, Havering and Redbridge University Hospitals NHS Trust - Sandwell and West Birmingham Hospitals NHS Trust, Karolinska Institutet - Karolinska University Hospital, UMR 1295 - CERPOP Centre d'Epidémiologie et de Recherche en santé des POPulations - INSERM, Bispebjerg and Frederiksberg Hospitals, University of Leipzig - University Hospital Leipzig, La Paz Carlos III Hospital, University of Lausanne - Center for Primary Care and Public Health, Ghent University - Ghent University Hospital, Medical University of Graz - Division of Endocrinology and Diabetology, Medical University of Graz, Utrecht University - Department of Vascular Medicine, University of Milan - Department of Pharmacological and Biomolecular Sciences and Independent