Laura Herring

University of North Carolina (UNC) at Chapel Hill - Proteomics Core Facility

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Tandem Detergent-Extraction and Immunoprecipitation of Proteinopathy (TDiP): Scalable Enrichment of ALS-Associated TDP-43 Aggregates

Number of pages: 38 Posted: 25 Oct 2022
Baggio Evangelista, Shannon Cahalan, Joey Ragusa, Angie Mordant, Julie Necarsulmer, Robert Perna, Tejazaditya Ajit, Kristen White, Natalie Barker, Xu Tian, Sarah Cohen, Rick Meeker, Laura Herring and Todd J. Cohen
University of North Carolina (UNC) at Chapel Hill - Department of Cell Biology and Physiology, University of North Carolina (UNC) at Chapel Hill - Institute on Aging (IOA), University of North Carolina (UNC) at Chapel Hill - Department of Cell Biology and Physiology, University of North Carolina (UNC) at Chapel Hill - Proteomics Core Facility, University of North Carolina (UNC) at Chapel Hill - Department of Cell Biology and Physiology, University of North Carolina (UNC) at Chapel Hill - Department of Neurology, University of North Carolina (UNC) at Chapel Hill - Department of Neurology, University of North Carolina (UNC) at Chapel Hill - Microscopy Services Laboratory, University of North Carolina (UNC) at Chapel Hill - Proteomics Core Facility, University of North Carolina (UNC) at Chapel Hill - Department of Neurology, University of North Carolina (UNC) at Chapel Hill - Department of Cell Biology and Physiology, University of North Carolina (UNC) at Chapel Hill - Department of Neurology, University of North Carolina (UNC) at Chapel Hill - Proteomics Core Facility and University of North Carolina (UNC) at Chapel Hill - Department of Neurology
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Abstract:

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Transactive response DNA binding protein (TDP-43), protein aggregation, protein purification, templated recruitment, prion-like transmission, post-translational modification, neurodegeneration, Proteomics, macrophage, microglia