University of Glasgow - School of Cardiovascular and Metabolic Health, University of Glasgow - Robertson Institute of Biostatistics and Clinical Trials Unit, University of Glasgow - School of Cardiovascular and Metabolic Health, University of Nottingham, Queen Elizabeth University Hospital - Department of Neuroradiology, University of Glasgow - School of Cardiovascular and Metabolic Health, University of East Anglia (UEA) - Department of Clinical Psychology, Queen Elizabeth University Hospital - Department of Neurology, University of Dundee - School of Medicine, University of Dundee - School of Medicine, University of Glasgow - College of Medical, Veterinary & Life Sciences, University of Glasgow - Institute of Neuroscience and Psychology, University of Dundee - Division of Molecular and Clinical Medicine, University of Glasgow - School of Medicine, Dentistry and Nursing, University Hospital Monklands - University Department of Stroke Care, Guy's and St Thomas' NHS Foundation Trust - Department of Stroke, Ageing and Health, University of Glasgow - School of Cardiovascular and Metabolic Health, University of Newcastle - Wolfson Unit of Clinical Pharmacology, Mid and South Essex University Hospitals Group - Department of Stroke Medicine, Leeds General Infirmary - Department of Neurology, University of Leeds, South West Acute Hospital - Department of Medicine, Government of the United Kingdom - Luton and Dunstable University Hospital, University of Aberdeen - Medical Sciences and Nutrition, Leeds Teaching Hospitals NHS Trust, Government of the United Kingdom - Royal United Hospitals Bath NHS Foundation Trust, Nottingham University Hospitals NHS Trust, University College London - UCL Queen Square Institute of Neurology and University of Glasgow - Robertson Institute of Biostatistics and Clinical Trials Unit