China Medical University - Department of Neurology, China Medical University - Department of Neurology, University of Eastern Finland - A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland - Department of Neurology, Shanghai Jiao Tong University (SJTU) - Department of Biochemistry and Molecular Cell Biology, China Medical University - Department of Geriatrics, China Medical University - Department of Neurology, China Medical University - Department of Neurology, China Medical University - Department of Neurology, China Medical University - Department of Neurology, China Medical University - Department of Neurology, China Medical University - Department of Neurology and China Medical University - Department of Neurology