Nanjing University - Department of Critical Care Medicine, Nanjing University - Department of Critical Care Medicine, Nanjing Medical University, Nanjing University - Department of Critical Care Medicine, Nanjing Medical University, University of Liverpool - Department of Public Health, Policy and Systems, Nanjing University - Department of Critical Care Medicine, Nanjing University - Department of Critical Care Medicine, University of Auckland - Surgical and Translational Research Centre, Guiqian International General Hospital - Department of Critical Care Medicine and Nanjing University - Department of Critical Care Medicine