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Yosuke Demizu

National Institute of Health Sciences

1-18-1, Kamiyoga

Setagaya-ku

Tokyo, 158-8501

Japan

  • National Institute of Health Sciences

SCHOLARLY PAPERS

6

DOWNLOADS

253

TOTAL CITATIONS

1

Scholarly Papers (6)

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1.

Development of Versatile Solid-Phase Methods for Syntheses of PROTACs with Diverse E3 Ligands

Number of pages: 23 Posted: 13 Apr 2023
Hanqiao Xu, Takashi Kurohara, Nobumichi Ohoka, Genichiro Tsuji, Takao Inoue, Mikihiko Naito and Yosuke Demizu
National Institute of Health Sciences, National Institute of Health Sciences, National Institute of Health Sciences, National Institute of Health Sciences, National Institute of Health Sciences, University of Tokyo and National Institute of Health Sciences
Downloads 74 (844,901)

Abstract:

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PROTAC, Solid-Phase synthesis, BRD4, Protein degradation

2.

Structure-Activity Relationship and Crystallographic Analyses of Non-Secosteroidal Vitamin D Receptor Ligands Bearing Diphenylsilane Core as a Hydrophobic Pharmacophore

Number of pages: 14 Posted: 12 Apr 2025
Hansaka Nirupama Thilakarathn Mudiyanselage, Takashi Misawa, Kotaro Ochiai, Yosuke Demizu, Yuya Hanazono, Nobutoshi Ito and Shinya Fujii
affiliation not provided to SSRN, National Institute of Health Sciences, affiliation not provided to SSRN, National Institute of Health Sciences, affiliation not provided to SSRN, affiliation not provided to SSRN and affiliation not provided to SSRN
Downloads 41 (1,170,409)

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vitamin D receptor, hydrophobic pharmacophore, silane, crystallographic analysis, hydrophobic interaction

3.

Mechanistic Study of Plasmid DNA Delivery by Magainin 2-Derived Stapled Peptides

Number of pages: 22 Posted: 12 Mar 2025
Motoharu Hirano, Yuki Takechi-Haraya, Yasuhiro Abe, Takashi Misawa, Norihito Shibata, Yoji Sato and Yosuke Demizu
National Institute of Health Sciences, National Institute of Health Sciences, National Institute of Health Sciences, National Institute of Health Sciences, National Institute of Health Sciences, National Institute of Health Sciences and National Institute of Health Sciences
Downloads 36 (1,236,159)

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Peptide/plasmid DNA complex, Intracellular delivery, Amphipathic peptide, Helical structure, Drug delivery systems

4.

Dual-Modified Penetratin Peptides: Enhancing Nucleic Acid Delivery Through Stapling and Endosomal Escape Domain

Number of pages: 19 Posted: 10 Jul 2024
Kanako Horikoshi, Maho Miyamoto, Keisuke Tsuchiya, Hidetomo Yokoo and Yosuke Demizu
Yokohama City University, Yokohama City University, Sanyo-Onoda City University, National Institute of Health Sciences and National Institute of Health Sciences
Downloads 36 (1,236,159)

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Cell-penetrating peptides, Stapling structures, Endosomal escape domain, Nucleic acid delivery, Penetratin, pDNA

5.

Photo-Regulated Protacs: A Novel Tool for Temporal Control of Targeted Protein Degradation

Number of pages: 7 Posted: 22 Mar 2024
Hanqiao Xu, Nobumichi Ohoka, Takao Inoue, Hidetomo Yokoo and Yosuke Demizu
Yokohama City University, National Institute of Health Sciences, National Institute of Health Sciences, National Institute of Health Sciences and National Institute of Health Sciences
Downloads 35 (1,249,711)
Citation 1

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PROTAC, Chemical tool, Photocleavable linker, Photo-caged group, ON-OFF type

6.

Photocleavable PROTACs as Tools for Dynamic Regulation of Protein Function

Number of pages: 29 Posted: 08 Oct 2025
Hanqiao Xu, Hidetomo Yokoo and Yosuke Demizu
Yokohama City University, National Institute of Health Sciences and National Institute of Health Sciences
Downloads 31 (1,304,549)

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Photocleavable PROTAC, Targeted Protein Degradation, UV irradiation, Temporal control, Nitrobenzyl linker