University of Birmingham - MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham - School of Biosciences, Karolinska Institutet, Karolinska University Hospital - Division of Rheumatology, Department of Medicine Solna, Leiden University - Leiden University Medical Center (LUMC), Newcastle University - Translational and Clinical Research Institute, University of Birmingham - MRC-ARUK Centre for Musculoskeletal Ageing Research, affiliation not provided to SSRN, University of Birmingham - MRC-ARUK Centre for Musculoskeletal Ageing Research and National Institute of Health Research Birmingham Biomedical Research Centre