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Olivia M. Merkel

Ludwig Maximilian University of Munich (LMU)

SCHOLARLY PAPERS

10

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1,074

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Scholarly Papers (10)

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1.

Evaluation of the Effects of Storage Conditions on Spray-Dried siRNA-LNPs Before and after Subsequent Drying

Number of pages: 17 Posted: 25 Aug 2023
Christoph M. Zimmermann, Paola Luciani and Olivia M. Merkel
Ludwig Maximilian University of Munich (LMU), University of Bern - Department of Chemistry, Biochemistry and Pharmaceutical Sciences and Ludwig Maximilian University of Munich (LMU)
Downloads 197 (386,064)

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Lipid nanoparticles, LNP, Onpattro®, RNA therapeutics, siRNA delivery, spray drying, pulmonary delivery, subsequent drying, storage, shelf life

2.

Antibody Oxidation and Impact of Formulation: A High-Throughput Screening Approach

Downloads 128 (565,439)

Antibody Oxidation and Impact of Formulation: A High-Throughput Screening Approach

Number of pages: 19 Posted: 18 Dec 2024
Paulina Luisa Fischer, Olivia M. Merkel, Michael Siedler, Tanja Meyer, Lucienne Nouchikian and Martin Huelsmeyer
affiliation not provided to SSRN, Ludwig Maximilian University of Munich (LMU), affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN and affiliation not provided to SSRN
Downloads 78 (826,467)

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Oxidation, monoclonal antibody therapeutics, Biopharmaceutics, Formulation Development, High Throughput Screening (HTS)

Antibody Oxidation and Impact of Formulation: A High-Throughput Screening Approach

Number of pages: 19 Posted: 18 Dec 2024
Paulina Luisa Fischer, Olivia M. Merkel, Michael Siedler, Tanja Meyer, Lucienne Nouchikian and Martin Huelsmeyer
affiliation not provided to SSRN, Ludwig Maximilian University of Munich (LMU), affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN and affiliation not provided to SSRN
Downloads 50 (1,083,731)

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Oxidation, monoclonal antibody therapeutics, Biopharmaceutics, Formulation Development, High Throughput Screening (HTS)

3.

Inhalable siRNA-LNP-based Dry Powder for the Treatment of Eosinophilic Asthma

Number of pages: 27 Posted: 01 Dec 2025
David C. Jürgens, Leonie Deßloch, Anna-Maria Mazzetta, Olivia M. Merkel and See PDF
Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU) and Please see PDF for full list of authors & affiliations
Downloads 127 (569,079)

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lipid nanoparticle, GATA3 silencing, spray drying, pulmonary drug delivery, siRNA delivery

4.

A Hybrid Polymeric System for Pulmonary mRNA Delivery: Advancing Mucosal Vaccine Development

Number of pages: 39 Posted: 09 Jul 2025
Min Jiang, Felix Sieber-Schäfer, Simone Carneiro, Dana Matzek, Anny Nguyen, Diana Leidy Porras-Gonzalez, Arun Kumar Verma, Miriam Kolog-Gulko, David C. Jürgens, Gerald Burgstaller, Bastian Popper, Xun Sun, Olivia M. Merkel and Sneak Peek Administrator
Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Helmholtz Zentrum Muenchen, Helmholtz Zentrum Muenchen, Daiichi Sankyo Europe, Ludwig Maximilian University of Munich (LMU), Helmholtz Zentrum Muenchen, Ludwig Maximilian University of Munich (LMU), Sichuan University, Ludwig Maximilian University of Munich (LMU) and Independent
Downloads 113 (626,371)

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Pulmonary delivery, Messenger RNA vaccine, Poly (beta-amino esters), Endosomal escape, Human precision cut lung slices

5.

Microfluidic Mixing as Platform Technology for Production of Chitosan Nanoparticles Loaded with Different Macromolecules

Number of pages: 31 Posted: 20 Mar 2023
Antonietta Greco, Bettina Gabold, Siyu Chen, Xiaoxuan Wang, Zehua Xu, Achim Hartschuh, Enrica Chiesa, Ida Genta, Christian L. Ried, Thomas Dr. Merdan and Olivia M. Merkel
University of Pavia, Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Department of Chemistry and Center for NanoScience, Department of Chemistry and Center for NanoScience, University of Pavia, University of Pavia, AbbVie Deutschland GmbH & Co. KG, AbbVie Deutschland GmbH & Co. KG and Ludwig Maximilian University of Munich (LMU)
Downloads 109 (645,052)

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Chitosan, siRNA, mRNA, protein, microfluidic, drug delivery systems, nanoplatforms

6.

Utilizing Chitosan Nanoparticles for the Delivery of Biologics to the Brain via Intranasal Route

Number of pages: 37 Posted: 02 Dec 2025
Bettina Gabold, Irene Gialdini, Igor Khalin, Olivia M. Merkel and See PDF
Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU) and Please see PDF for full list of authors & affiliations
Downloads 98 (704,534)

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Chitosan, Nanoparticles, nose-to-brain, intranasal administration, Fluorescence Correlation Spectroscopy, in vivo

7.

Machine Learning on a Small Orthogonal Polymer Library Reveals Functional Insights and Optimizes Pbae Copolymer Synthesis and Performance

Number of pages: 28 Posted: 01 Jul 2025
Felix Sieber-Schäfer, Adrian P. E. Kromer, Müge Molbay, Simone Carneiro, Min Jiang, Anny Nguyen, Joschka Müller, Johan Farfan Benito and Olivia M. Merkel
Ludwig Maximilian University of Munich (LMU), affiliation not provided to SSRN, affiliation not provided to SSRN, Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), affiliation not provided to SSRN, affiliation not provided to SSRN and Ludwig Maximilian University of Munich (LMU)
Downloads 89 (759,537)

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PBAE polymers, siRNA Delivery, Machine Learning, Orthogonal Library, in vivo - in vitro correlation

8.

Cellular EMT-Status Governs Contact Guidance in an Electrospun TACS-Mimicking in Vitro Model

Number of pages: 30 Posted: 12 Nov 2024
Lorenz Isert, Mehak Passi, Benedikt Freystetter, Maximilian Grab, Andreas Roidl, Christoph Müller, Aditi Mehta, Harini Sundararaghavan, Stefan Zahler and Olivia M. Merkel
Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Wayne State University, Ludwig Maximilian University of Munich (LMU) and Ludwig Maximilian University of Munich (LMU)
Downloads 87 (759,537)

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Breast cancer, EMT, electrospun fibers, morphology, nuclear circularity, cellular stiffness

9.

Dual-Delivery Transdermal Platform Integrating Biomimetic Self-Adjuvant Vaccines in Polymeric Microneedles for Enhanced Immunity

Number of pages: 56 Posted: 25 Aug 2023
Min Jiang, Yuandong Zhang, Tao Zheng, Yu Chang, Nan Qiao, Ming Qin, Penghui He, Chunting He, Guangsheng Du, Olivia M. Merkel and Xun Sun
Sichuan University, Zunyi Medical University, Sichuan University, Sichuan University, Sichuan University, Sichuan University, Sichuan University, Sichuan University, Sichuan University, Ludwig Maximilian University of Munich (LMU) and Sichuan University
Downloads 75 (837,727)

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polymeric microneedles, transdermal delivery, self-adjuvant carriers, glucan particles, subunit vaccines

10.

New insights into the intrinsic tryptophan fluorescence emission spectra of IgG antibodies and the impact of protein unfolding and aggregation

Number of pages: 28 Posted: 03 Mar 2026 Last Revised: 17 May 2026
Lennart Brack, Jonas Binder, Irene Gialdini, Don Lamb, Wolfgang Friess, Olivia M. Merkel and Rudolf Schroeder
affiliation not provided to SSRN, affiliation not provided to SSRN, Ludwig Maximilian University of Munich (LMU), affiliation not provided to SSRN, Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU) and affiliation not provided to SSRN
Downloads 51 (1,052,702)

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intrinsic tryptophan fluorescence emission, IgG1, protein unfolding, protein aggregation, fluorescence quenching