Government of the People's Republic of China - Department of Anorectal Surgery, Shanghai Jiao Tong University (SJTU) - State Key Laboratory of Oncogenes and Related Genes, Tongji University - Shanghai Key Laboratory of Signaling and Disease Research, Chinese Academy of Sciences (CAS) - Institute of Basic Medicine and Cancer (IBMC), Government of the People's Republic of China - Department of Gastrointestinal Surgery, Tongji University - Department of Ultrasound in Medicine, Government of the People's Republic of China - Department of Anorectal Surgery, Chinese Academy of Sciences (CAS) - Institute of Basic Medicine and Cancer (IBMC), Government of the People's Republic of China - Department of Anorectal Surgery, Government of the People's Republic of China - Department of Anorectal Surgery and Fudan University - Department of Colorectal Surgery