The University of Manchester - Manchester Centre for Health Economics, The University of Manchester - Manchester Centre for Health Economics, University of Cambridge - Wellcome Trust-MRC Institute of Metabolic Science, University of East Anglia (UEA) - Norwich Medical School, NHS England and NHS Improvement - Getting It Right First Time Programme, The Adam Practice, Government of the United Kingdom - Academic Department of Diabetes & Endocrinology, University of Birmingham - Institute of Immunology and Immunotherapy, The University of Manchester - Centre for Biostatistics, The University of Manchester - Centre for Women’s Mental Health, The University of Manchester - Manchester Clinical Trials Unit, The University of Manchester - Division of Diabetes, Endocrinology and Gastroenterology, University Hospitals of Derby and Burton NHS Foundation Trust and The University of Manchester - Manchester University NHS Foundation Trust