Capital Medical University - Department of Gastroenterology, Capital Medical University - Department of Gastroenterology, Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - Department of Thoracic Surgery, Capital Medical University - National Clinical Research Center for Digestive Diseases, Echo Biotech Co., Ltd., Echo Biotech Co., Ltd., Capital Medical University - National Clinical Research Center for Digestive Diseases and Capital Medical University - National Clinical Research Center for Digestive Diseases