University of Oxford - Department of Physiology, Anatomy & Genetics, University of Oxford - Department of Physiology, Anatomy & Genetics, Fundação Calouste Gulbenkian - Instituto Gulbenkian de Ciência, Fundação Calouste Gulbenkian - Instituto Gulbenkian de Ciência, University of Oxford - Department of Physiology, Anatomy & Genetics, University of Oxford - Department of Physiology, Anatomy & Genetics, Universidade de Santiago de Compostela - NeurObesity Group, University of Oxford - Department of Physiology, Anatomy & Genetics, University of Oxford - Department of Physiology, Anatomy & Genetics, University of Oxford - MRC Weatherall Institute of Molecular Medicine, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Vita Salute San Raffaele University, Vita Salute San Raffaele University, Universidade de Santiago de Compostela, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN) and University of Oxford - Department of Physiology, Anatomy & Genetics