Case Western Reserve University - School of Medicine, Case Western Reserve University - Department of Genetics and Genome Sciences, Case Western Reserve University - Department of Genetics and Genome Sciences, Case Western Reserve University - Department of Genetics and Genome Sciences, Case Western Reserve University - Department of Genetics and Genome Sciences, Case Western Reserve University - School of Medicine, Case Western Reserve University - Department of Genetics and Genome Sciences, Harvard University - Boston Children’s Hospital, Mayo Clinic - Mayo Clinic College of Medicine, Harvard University - Boston Children’s Hospital and Harvard University - Boston Children’s Hospital