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Brian S. Appleby

Case Western Reserve University - Department of Pathology

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Scholarly Papers (1)

1.

Large-Scale Validation of Skin Prion Seeding Activity as a Biomarker for Postmortem Diagnosis of Creutzfeldt-Jakob Disease

Number of pages: 25 Posted: 08 May 2023
Case Western Reserve University - Department of Pathology, Government of the United States of America - Laboratory of Persistent Viral Diseases, Case Western Reserve University - Department of Pathology, Case Western Reserve University - Department of Pathology, Case Western Reserve University - Department of Pathology, Case Western Reserve University - Department of Pathology, Case Western Reserve University - Department of Pathology, Case Western Reserve University - National Prion Disease Pathology Surveillance Center, Case Western Reserve University - Department of Pathology, Case Western Reserve University - Department of Pathology, Case Western Reserve University - National Prion Disease Pathology Surveillance Center, Case Western Reserve University - Department of Pathology, Case Western Reserve University - Department of Pathology, Case Western Reserve University - Department of Pathology, Nanchang University - Department of Neurology, Jilin University (JLU) - Department of Neurology, Government of the United States of America - Laboratory of Persistent Viral Diseases, Government of the United States of America - Division of High-Consequence Pathogens and Pathology, University of Pittsburgh - Department of Medicine, Case Western Reserve University - Department of Pathology, Government of the United States of America - Virus and Prion Research Unit, Case Western Reserve University - Department of Pathology, Case Western Reserve University - Department of Pathology, Government of the United States of America - Laboratory of Persistent Viral Diseases and Case Western Reserve University - Department of Pathology
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Abstract:

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Biomarker, Creutzfeldt-Jakob disease (CJD), prion, real-time quaking-induced conversion (RT-QuIC), protein misfolding cyclic amplification (PMCA), seeding activity (SA), and skin