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University of Brescia - Department of Clinical and Experimental Sciences, University of Brescia - Department of Clinical and Experimental Sciences, University of Brescia - Department of Clinical and Experimental Sciences, ASST-Spedali Civili of Brescia - Department of Anesthesia, University of Brescia - Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia - Department of Molecular and Translational Medicine, University of Brescia - Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia - Department of Clinical and Experimental Sciences, University of Brescia - Department of Clinical and Experimental Sciences, ASST-Spedali Civili of Brescia - Department of Anesthesia, ASST-Spedali Civili of Brescia - Department of Continuity of Care and Frailty, University of Brescia - Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia - Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia - Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Toronto - Department of Medicine, ASST Monza - Department of Emergency and Intensive Care, University of Brescia - Department of Clinical and Experimental Sciences, University of Brescia - Department of Clinical and Experimental Sciences, ASST-Spedali Civili of Brescia - Intensive Care and Emergency and ASST-Spedali Civili of Brescia - Department of Anesthesia