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Feng Ren

Insilico Medicine Shanghai Ltd.

SCHOLARLY PAPERS

5

DOWNLOADS

433

TOTAL CITATIONS

2

Scholarly Papers (5)

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1.

Discovery of Novel MAT2A Inhibitors by an Allosteric Site-Compatible Fragment Growing Approach

Number of pages: 18 Posted: 10 Jan 2024
Feng Gao, Xiaoyu Ding, Zhongying Cao, Wei Zhu, Yaya Fan, Barbara Steurer, Hailong Wang, Xin Cai, Man Zhang, Alex Aliper, Feng Ren, Xiao Ding and Alex Zhavoronkov
Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine AI Limited, Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd. and Insilico Medicine Shanghai Ltd.
Downloads 131 (558,171)

Abstract:

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MAT2A Inhibitor, MTAP-deficient Tumor, Fragment Growing

2.

Synthesis and Structure-Activity Optimization of Azepane-Containing Derivatives as PTPN2/PTPN1 Inhibitors

Number of pages: 20 Posted: 19 Mar 2024
Jiamin Zheng, Zhisen Zhang, Xiaoyu Ding, Deheng Sun, Lihua Min, Feng Wang, Sujing Shi, Xin Cai, Man Zhang, Alex Aliper, Feng Ren, Xiao Ding and Alex Zhavoronkov
Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine AI Limited, Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd. and Insilico Medicine Shanghai Ltd.
Downloads 111 (635,507)

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3.

Discovery of Novel and Selective SIK2 Inhibitors by the Application of Alphafold Structures and Generative Models

Number of pages: 26 Posted: 26 Jun 2023
Wei Zhu, Xiaosong Liu, Qi Li, Feng Gao, Tingting Liu, Xiaojing Chen, Man Zhang, Alex Aliper, Feng Ren, Xiao Ding and Alex Zhavoronkov
Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine AI Limited, Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd. and Insilico Medicine Shanghai Ltd.
Downloads 99 (704,534)

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Salt-inducible kinase 2, AlphaFold, Generative Models, Novel Selectivity

4.

Discovery of Pyrrolopyrimidinone Derivatives as Potent Pkmyt1 Inhibitors for the Treatment of Cancer

Number of pages: 12 Posted: 01 Oct 2024
Chao Wang, Yazhou Wang, Fanye Meng, Tingting Liu, Xiaomin Wang, Xin Cai, Man Zhang, Alex Aliper, Feng Ren, Alex Zhavoronkov and Xiao Ding
affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Insilico Medicine Shanghai Ltd., affiliation not provided to SSRN, Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine AI Limited, Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd. and Insilico Medicine Shanghai Ltd.
Downloads 59 (970,490)

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PKMYT1 inhibitor, Pyrrolopyrimidinone, Metabolic stability, Molecular docking

5.

Discovery of 1(2h)-Phthalazinone and 1(2h)-Isoquinolinone Derivatives as Potent Hematopoietic Progenitor Kinase 1 (Hpk1) Inhibitors

Number of pages: 33 Posted: 01 Aug 2024
Jingjing Peng, Xiaoyu Ding, Pei-Yu Shih, Qingyuan Meng, Xiao Ding, Man Zhang, Alex Aliper, Feng Ren, Hongfu Lu and Alex Zhavoronkov
affiliation not provided to SSRN, Insilico Medicine Shanghai Ltd., affiliation not provided to SSRN, affiliation not provided to SSRN, Insilico Medicine Shanghai Ltd., Insilico Medicine Shanghai Ltd., Insilico Medicine AI Limited, Insilico Medicine Shanghai Ltd., affiliation not provided to SSRN and affiliation not provided to SSRN
Downloads 33 (1,290,922)
Citation 2

Abstract:

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HPK1, T cell activation, favorable PK profile, anti-tumor activity