affiliation not provided to SSRN, affiliation not provided to SSRN, Huazhong University of Science and Technology, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Huazhong University of Science and Technology - Cancer Centre, Huazhong University of Science and Technology - Cancer Center, affiliation not provided to SSRN, Huazhong University of Science and Technology, Huazhong University of Science and Technology, Wuhan University, Huazhong University of Science and Technology, affiliation not provided to SSRN and affiliation not provided to SSRN