Harvard University - Division of Pulmonary and Critical Care Medicine, Harvard University - Division of Pulmonary and Critical Care Medicine, Ben-Gurion University of the Negev - Department of Life Sciences, Harvard University - Division of Pulmonary and Critical Care Medicine, Harvard University - Division of Pulmonary and Critical Care Medicine, Harvard University - Division of Pulmonary and Critical Care Medicine, Mayo Clinic - Department of Cardiovascular Medicine, McGill University - McGill University Health Centre, Harvard Medical School, Harvard University - Division of Pulmonary and Critical Care Medicine, University of Pittsburgh - Department of Emergency Medicine, affiliation not provided to SSRN, Harvard-MIT Health Sciences and Technology - Broad Institute of MIT Harvard, Harvard University - Department of Emergency Medicine, Wellcome Sanger Institute - Wellcome Genome Campus, St. Jude Children’s Research Hospital - Department of Computational Biology, Harvard University - Division of Pulmonary and Critical Care Medicine and Harvard Medical School