Boston University - Department of Biostatistics, South African Medical Research Council, Stellenbosch University - DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Boston University - Boston Medical Center, Brewelskloof Hospita, Boston University - Department of Epidemiology, Duke University - School of Medicine, Boston University - Boston Medical Center, Stellenbosch University - DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Harvard University - Harvard Medical School, South African Medical Research Council - Alcohol, Tobacco and Other Drug Research Unit, University of Cape Town (UCT) - Institute of Infectious Disease and Molecular Medicine, Stellenbosch University, Boston University - School of Public Health, Boston University - Department of Biostatistics, Stellenbosch University - Division of Molecular Biology and Human Genetics and Boston University - Chobanian & Avedisian School of Medicine