University of Freiburg - Institute for Immunodeficiency, University of Freiburg - Institute of Medical Biometry and Statistics, University of Freiburg - Institute for Immunodeficiency, University of Freiburg - Institute for Immunodeficiency, University of Freiburg - Institute for Immunodeficiency, University of Leipzig - Department for Pediatric Immunology, Rheumatology & Infectiology, University of Freiburg - Institute for Immunodeficiency, University of Freiburg - Institute for Immunodeficiency, UCB Pharma, Belgium - Data & Translational Sciences, UCB Biopharma, University of Oxford - Wellcome Trust Centre for Human Genetics, Charité - Universitätsmedizin Berlin - Department of Paediatric Respiratory Medicine, Immunology, and Critical Care Medicine, CHI at Crumlin - Department of Paediatric Immunology, University Hospital Erlangen - Department of Hematology and Oncology, University of Duisburg-Essen - Department of Pediatric Hematology-Oncology, University Medical Center Eppendorf - Division of Pediatric Stem Cell Transplantation and Immunology, Comenius University - Department of Pediatric Hematology and Oncology, Muenster University Hospital - Department of General Paediatrics, University of Newcastle - Newcastle University Translational and Clinical Research Institute, University Hospital Regensburg, Stuttgart Cancer Center, St. Anna Children's Cancer Research Institute (CCRI), University of Freiburg - Division of Pediatric Hematology and Oncology, Independent, University of Freiburg - Institute of Medical Biometry and Statistics, University of Ulm - Institute for Transfusion Medicine, University of Ulm - Institute for Transfusion Medicine, University of Freiburg - Institute for Immunodeficiency, University of Freiburg - Institute for Immunodeficiency and University of Freiburg - Institute for Immunodeficiency