Central South University - Department of Dermatology, Central South University, Central South University - Department of Dermatology, Central South University - Hunan Key Laboratory of Cancer Metabolism, Central South University - Department of Dermatology, Central South University, Central South University, Central South University, Central South University - Department of Dermatology, Central South University, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - Department of Pharmacy, Fraser Institute, Central South University - Hunan Key Laboratory of Medical Epigenomics and Central South University - Department of Dermatology