Department of Radiation Oncology, University Medical Center Mainz, affiliation not provided to SSRN, Heidelberg University - University Hospital Heidelberg, Heidelberg University - University Hospital Heidelberg, Heidelberg University, Heidelberg University, Heidelberg University - University Hospital Heidelberg, Heidelberg University - University Hospital Heidelberg, Heidelberg University - University Hospital Heidelberg, Heidelberg University - University Hospital Heidelberg, Heidelberg University - University Hospital Heidelberg, Heidelberg University - University Hospital Heidelberg, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, German Cancer Research Center (DKFZ) and Heidelberg University - University Hospital Heidelberg