affiliation not provided to SSRN, Shanghai University of Medicine and Health Sciences, Fudan University, affiliation not provided to SSRN, affiliation not provided to SSRN, Fudan University, Fudan University, Johns Hopkins University, Fudan University - Department of Epidemiology, affiliation not provided to SSRN, Fudan University, affiliation not provided to SSRN, Shanghai Jiao Tong University (SJTU) - Department of Molecular Diagnostics and Endocrinology, Shanghai University of Medicine and Health Sciences, Shanghai University of Medicine and Health Sciences, Shanghai University of Medicine and Health Sciences, Georgia Institute of Technology, Shanghai University of Medicine and Health Sciences and Fudan University