University of Pisa, University of Pisa, University of Pisa, Fondazione Toscana Gabriele Monasterio, University of Pisa, Fondazione Toscana Gabriele Monasterio, University of Pisa, Catholic University of Milan, University of Messina, ASL 2 Abruzzo Lanciano-Vasto-Chieti, Fondazione Toscana Gabriele Monasterio, University of Siena, - Department of Translational Medicine, Catholic University of Milan, University of Messina, MedStar Health Research Institute, Istituti Clinici Scientifici Maugeri IRCCS and Azienda Ospedaliero-Universitaria - Cardiology Division