affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, - Hospital General Universitario Gregorio Marañón, Great Ormond Street Hospital for Children, Utrecht University - University Medical Center (Utrecht), Erasmus University Rotterdam (EUR) - Department of Paediatric Intensive Care and Aarhus University - Research Center for Emergency Medicine