Sapienza University of Rome, Sapienza University of Rome, Sapienza University of Rome, Sapienza University of Rome, Basque Research and Technology Alliance (BRTA) - Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Center for Biomedical Research in the Liver and Digestive Diseases Network (CIBERehd) - CIC bioGUNE, Center for Biomedical Research in the Liver and Digestive Diseases Network (CIBERehd) - CIC bioGUNE, Center for Biomedical Research in the Liver and Digestive Diseases Network (CIBERehd) - CIC bioGUNE and Sapienza University of Rome