affiliation not provided to SSRN, Diabetes Research Unit, Cardiovascular Analytics Group, Hong Kong, China-UK Collaboration, Shanghai Jiao Tong University (SJTU) - School of Medicine, Xi'an Jiaotong University (XJTU), The University of Hong Kong - University of Hong Kong, Xi'an Jiaotong University (XJTU) - Cardiovascular Department, Prince of Wales Hospital, The Chinese University of Hong Kong (CUHK) - School of Life and Health Sciences, Tianjin Medical University - Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, The University of Hong Kong - Division of Clinical Pharmacology and Therapeutics, Tianjin Medical University - The Second Hospital of Tianjin Medical University and The University of Hong Kong - Department of Family Medicine and Primary Care