Heidelberg University, Heidelberg University, affiliation not provided to SSRN, University of Arkansas for Medical Sciences, Bruker Biospin GmbH, Heidelberg University, Heidelberg University, affiliation not provided to SSRN, Heidelberg University, University of Tübingen - University Hospitals Tübingen, affiliation not provided to SSRN, University of Pittsburgh - School of Medicine, Christian Albrechts University Kiel and University of Brescia - Department of Clinical and Experimental Sciences