Polytechnic University of Milan, Polytechnic University of Milan, University Hospital Basel - University Heart Center, Kantonsspital St Gallen, Ospedale Regionale di Lugano, affiliation not provided to SSRN, University of Bern - Inselspital, University of Bern - Inselspital, University of Bern - Department of Cardiology, University of Basel - University Hospital Basel, Istituto Cardiocentro Ticino, University of Basel - Cardiovascular Research Institute Basel (CRIB), McMaster University, Istituto Cardiocentro Ticino and Polytechnic University of Milan