University of Amsterdam, Reinier de Graaf Gasthuis, University of Florence - Azienda Ospedaliero Universitaria Careggi, University of Milan - IRCCS Istituto Auxologico Italiano, University of Campania Luigi Vanvitelli, Ente Ospedaliero Ospedali Galliera, University of Florence - Azienda Ospedaliero Universitaria Careggi, Karolinska Institutet - Karolinska University Hospital, Vanvitelli University of Campania Luigi Vanvitelli, University of Florence - Azienda Ospedaliero Universitaria Careggi, IRCCS Istituto Auxologico Italiano - Department of Endocrine and Metabolic Diseases, University of Milan - IRCCS Istituto Auxologico Italiano and Karolinska Institutet - Karolinska University Hospital