University of Pittsburgh - Department of Human Genetics, University of British Columbia (UBC) - Centre for Heart Lung Innovation, University of British Columbia (UBC) - Centre for Heart Lung Innovation, University of British Columbia (UBC) - Centre for Heart Lung Innovation, University of Nottingham, University of Pennsylvania, University of Pittsburgh - Department of Environmental and Occupational Health, University of Pittsburgh, University of Calgary - Division of Respiratory Medicine, University of Pittsburgh, University of Pittsburgh, University of Pittsburgh - Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Medical University of South Carolina, University of British Columbia (UBC) - Centre for Heart Lung Innovation, University of British Columbia (UBC) - Centre for Heart Lung Innovation, University of Pittsburgh, University of British Columbia (UBC) - Centre for Heart Lung Innovation, University of Pittsburgh - Medical Center (UPMC), University of British Columbia (UBC) - Division of Respiratory Medicine, University of British Columbia (UBC) - Centre for Heart Lung Innovation and University of Pittsburgh - Department of Medicine and Pulmonary and Critical Care Medicine