affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of the Basque Country, Biogipuzkoa Health Research Institute, Biogipuzkoa Health Research Institute, IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" (IRST) - Clinical and Experimental Oncology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" (IRST) - Clinical and Experimental Oncology Unit, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, IRCCS Istituto Ortopedico Rizzoli di Bologna, affiliation not provided to SSRN and affiliation not provided to SSRN