Fukushima Medical University, affiliation not provided to SSRN, affiliation not provided to SSRN, University of New South Wales (UNSW), Cairo University, St. Jude Children’s Research Hospital - Department of Global Pediatric Medicine and Oncology, St. Jude Children’s Research Hospital, University College London - Great Ormond Street Institute of Child Health, affiliation not provided to SSRN, Aga Khan University, Kenyatta National Hospital and affiliation not provided to SSRN