Istituto Oncologico Veneto – IRCCS, SOLTI Breast Cancer Research Group, European Institute of Oncology (IEO) IRCCS - Division of New Drugs and Early Drug Development for Innovative Therapies, IRCCS-Fondazione Bietti, University of Genova - Department of Internal Medicine and Medical Specialties (DiMI), University of Piemonte Orientale, Universidad Católica de Salta, - Hospital General Universitario Gregorio Marañón, IRCCS Ospedale Policlinico San Martino, Hospital Clinic of Barcelona - Department of Medical Oncology, Università degli Studi di Udine and Vall d’Hebron Institute of Oncology (VHIO)