University of Zurich, University of Bern, University of Bern, University of Bern, University of Bern, Kantonsspital Olten, NHS Foundation Trust, University of Cambridge - Wellcome Trust-MRC Institute of Metabolic Science, University of Bern - University Institute of Clinical Chemistry, University of Cambridge - Wellcome Trust-MRC Institute of Metabolic Science, University of Bern, University of Zurich and University of Bern