affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, H. Lee Moffitt Cancer Center and Research Institute, affiliation not provided to SSRN, University of Virginia - University of Virginia Health System, Tufts University - Tufts Medical Center, University of Arkansas for Medical Sciences, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Tufts University - Tufts Medical Center, University of Arkansas for Medical Sciences, affiliation not provided to SSRN and University of Minnesota - Minneapolis