University of Pittsburgh, University of Pennsylvania, University of Colorado Anschutz Medical Campus, affiliation not provided to SSRN, University of Pittsburgh, University of Pittsburgh, University of Pittsburgh, University of Pittsburgh, University of Pittsburgh, University of Pittsburgh, affiliation not provided to SSRN, Pennsylvania State University, University of Minnesota - Minneapolis, Medical University of South Carolina, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Children's Mercy Hospital and University of Pittsburgh