affiliation not provided to SSRN, affiliation not provided to SSRN, University of Montpellier - Institut régional du Cancer de Montpellier, German Cancer Research Center (DKFZ), Fondazione IRCCS Istituto Nazionale dei Tumori, affiliation not provided to SSRN, The University of Manchester, Government of the United Kingdom, Department of Health, National Health Service (NHS), Mount Vernon Cancer Centre Northwood, affiliation not provided to SSRN, KU Leuven, German Cancer Research Center (DKFZ), affiliation not provided to SSRN, University of Heidelberg, University of Leicester, University of Leicester, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Leicester, affiliation not provided to SSRN, affiliation not provided to SSRN, Maastricht University, affiliation not provided to SSRN, Ghent University, University of Leicester, The University of Manchester - Translational Radiobiology Group, The University of Manchester and The University of Manchester