default author photo

Thomas Hanke

Goethe University Frankfurt

Grüneburgplatz 1

Frankfurt am Main, 60323

Germany

  • Goethe University Frankfurt

SCHOLARLY PAPERS

3

DOWNLOADS

140

TOTAL CITATIONS

0

Scholarly Papers (3)

Actions:
Email selected abstracts
1.

Discovery and Development of a Potent LIMK2 Isoform-Specific Degrader

Number of pages: 89 Posted: 02 Sep 2025
Kamal Rayees Abdul Azeez, Hayuningbudi Saraswati, Thorsten Mosler, Thomas Hanke, Hung xuan Ho, Noah Neder, Saran Aswathaman Sivashanmugam, Marcel Heinz, Martin-Peter Schwalm, Giulio Giuliani, Rajeshwari Rathore, Rubina Kazi, Rahul Kumar, Marko Mitrovic, Cristian Prieto-Garcia, Henry J. Bailey, Sebastian Mathea, Gerhard Hummer, Ivan Dikic, Susanne Müller, Alexandra Stolz, Daniela S. Krause, Stefan Knapp and Sneak Peek Administrator
Goethe University Frankfurt, Johannes Gutenberg University Mainz, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Max Planck Institute of Biophysics, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Johannes Gutenberg University Mainz, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Max Planck Institute of Biophysics, Goethe University Frankfurt, Goethe University Frankfurt - Structural Genomics Consortium, Goethe University Frankfurt, Johannes Gutenberg University Mainz, Goethe University Frankfurt - Institute of Pharmaceutical Chemistry and Independent
Downloads 80 (803,225)

Abstract:

Loading...

LIM Kinases, LIMK2, Targeted Protein Degradation, PROTAC, Isoform-Specificity

2.

Synthesis and Evaluation of Chemical Linchpins for Highly Selective Ck2α Targeting

Number of pages: 61 Posted: 31 May 2024
Francesco A. Greco, Andreas Krämer, Laurenz Wahl, Lewis Elson, Theresa A. L. Ehret, Joshua Gerninghaus, Janina Möckel, Susanne Müller, Thomas Hanke and Stefan Knapp
Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt - Structural Genomics Consortium, Goethe University Frankfurt and Goethe University Frankfurt - Institute of Pharmaceutical Chemistry
Downloads 33 (1,277,121)

Abstract:

Loading...

Casein kinase 2, allosteric inhibitor, inhibitor binding mode, rational inhibitor design, inhibitor selectivity

3.

Development of Pyrazolo[1,5-A]Pyrimidine Based Macrocyclic Kinase Inhibitors Targeting Aak1

Number of pages: 30 Posted: 15 Apr 2025
Theresa E. Mensing, Christian G. Kurz, Jennifer A. Amrhein, Theresa A. L. Ehret, Franziska Preuss, Sebastian Mathea, Marwah Karim, Do Hoang Nhu Tran, Zuzana Kadlecova, Tuomas Tolvanen, Daniel Martinez-Molina, Susanne Müller, Shirit Einav, Stefan Knapp and Thomas Hanke
Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Goethe University Frankfurt, Stanford University, Stanford University, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Goethe University Frankfurt - Structural Genomics Consortium, Stanford University, Goethe University Frankfurt - Institute of Pharmaceutical Chemistry and Goethe University Frankfurt
Downloads 27 (1,372,601)

Abstract:

Loading...

AAK1, BIKE, kinase inhibitors, macrocycles, Antiviral, NAK