affiliation not provided to SSRN, Fudan University - Institutes of Biomedical Sciences, Fudan University, Tsinghua University, Fudan University, Beijing Institute of Lifeomics - Beijing Proteome Research Center, Fudan University - State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development and Fudan University - State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development