Sapienza University of Rome, Sapienza University of Rome, University of Turin - Department of Cardiology, University of Turin, University of Trieste, University of Trieste, AOU Città della Salute e della Scienza di Torino, University of Siena, Sapienza University of Rome, Azienda Ospedaliera Universitaria Di ferrara, AOU Città della Salute e della Scienza di Torino, Scuola Superiore Sant’Anna, University of Palermo, Padua University - Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Udine, University of Trieste, IRCCS Ospedale Policlinico San Martino, affiliation not provided to SSRN, University of Palermo, affiliation not provided to SSRN, "Sapienza" University of Rome - Department of Cardiovascular and Respiratory Diseases, Sapienza University of Rome, University of Padua - University Hospital, Magna Graecia University of Catanzaro, University of Naples Federico II, University of Trieste and Sapienza University of Rome