Sapienza University of Rome - Department of Physiology and Pharmacology, Sapienza University of Rome - Department of Physiology and Pharmacology, IRCCS Synlab SDN, Oasi Research Institute - IRCCS, affiliation not provided to SSRN, University of Cassino and Southern Lazio, Hospital San Raffaele Cassino, Oasi Research Institute - IRCCS, University of Naples Parthenope, IRCCS Synlab SDN, IRCCS San Raffaele Pisana, IRCCS San Raffaele Pisana, IRCCS San Raffaele Pisana, Università degli Studi di Genova, Università degli Studi di Genova, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Istanbul Medipol University, Istanbul Medipol University, Istanbul Medipol University, Dokuz Eylul University, affiliation not provided to SSRN, IRCCS Centro San Giovanni di Dio Fatebenefratelli and Sapienza University of Rome - Department of Physiology and Pharmacology