affiliation not provided to SSRN, The University of Manchester - Manchester University NHS Foundation Trust, The University of Manchester - Manchester University NHS Foundation Trust, The University of Manchester - Manchester Thoracic Oncology Centre (MTOC), The University of Manchester - Manchester University NHS Foundation Trust, The University of Manchester - Manchester University NHS Foundation Trust, The University of Manchester - Manchester University NHS Foundation Trust, The University of Manchester - Manchester University NHS Foundation Trust, The University of Manchester - Manchester University NHS Foundation Trust, The University of Manchester - Manchester University NHS Foundation Trust, The University of Manchester - Manchester University NHS Foundation Trust, The University of Manchester - Manchester University NHS Foundation Trust, The University of Manchester - Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre - The Christie NHS Foundation Trust, The University of Manchester - Manchester University NHS Foundation Trust, The University of Manchester - Manchester University NHS Foundation Trust, affiliation not provided to SSRN, affiliation not provided to SSRN, The Christie NHS Foundation Trust, affiliation not provided to SSRN, Manchester Academic Health Sciences Centre - The Christie NHS Foundation Trust, Manchester Academic Health Sciences Centre - The Christie NHS Foundation Trust and The University of Manchester - Manchester University NHS Foundation Trust