Shandong First Medical University, Shandong First Medical University, Shandong Academy of Medical Sciences, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Shandong First Medical University, affiliation not provided to SSRN, Shandong First Medical University, Shandong First Medical University, affiliation not provided to SSRN, Tianjin Medical University - The Second Hospital of Tianjin Medical University and Chinese Academy of Sciences (CAS)